Dana Abduladhim Abdullatif
Dhahran Ahliyya Schools, Dammam, KSA, SAUDI ARABIA
Catalysts currently used to synthesize D- Form amino acids are expensive due to their sensitivity to moisture –H2O- and oxygen, limited substrate scope, high PTC loading, and toxicity. Analysis of conventional Phase- Transfer Catalysts (PTCs) has shown using long hydrocarbon chains is the cause to most disadvantages. Therefore, the purpose is to create a novel efficient organocatalyst, also taking into consideration the industrial and environmental perspectives. Pentanidium was used as a substitute organic catalyst because it gains its properties due to its asymmetrical structure, its inorganic ions, and functional groups containing fluorine or trifluorocarbonate.
After conducting the synthesis twice, through five phase-transfer reactions, using diphenylethanediamine as a precursor, Pentanidium is efficiently synthesized. Thin Layer Chromotography (TLC) and Nuclear Magentic Resonance (NMR) spectra were conducted regularly through every reaction of the synthesis.
Scientifically, objectives are met (consumed material/ reactants) and steps are reduced, where yield after finalizing the synthesis is 5.183 g/ 5.61 g x 100= 93% meaning that only 7% of reactants is loosed throughout the synthesis. Industrially, cost of the synthesis is merely 484 Euros of one container for every reactant. Environmentally, PTC is less toxic (less hydrocarbons involved).
In conclusion, pharmaceutical industries can depend more on Pentanidium, capable of producing D- Form amino acids. These amino acids are crucial; they are the initial and activating ingredients of pharmaceutical products, as well as cosmetics and, and even detergents.