Hassan Nezar Khdary, Khaled Alkozman
Manarat Al-Riyadh School, Riyadh, SAUDI ARABIA
Malaria kills 1 to 2 million people annually according to WHO reports. The problem is that the malaria parasite resists most medicines used to kill it because there are 12 hours in which the parasite mutates and resists the drug. The current project aims at producing a novel compound of medication using silica nanoparticles to effectively eradicate malaria in an expedient timeframe. The procedure starts with producing silica nanoparticles with 100 nanometer diameter. Next, the surface of the particles is functionalized with the Di-amine. Then, the silica nanoparticles are linked with 2 active malaria drugs. Then the 4 compounds undergo IR test to decide if the compounds have linked with the silica nanoparticles or not. Finally, the effectiveness of the new compound is tested by comparison with the medicines without silica nanoparticles. It takes 15 minutes to kill parasites with 50 mg of current medicine. On the other hand nanoparticles could be linked with 2 drugs will decrease the time to few second it takes one tenth the time that drugs without silica nanoparticles take. Laboratory experiments proved the effectiveness of silica nanoparticles in eradicating malaria. Using silica nanoparticles in treating malaria will contribute to eliminating malaria. This new method will open new prospects to eliminating other diseases caused by parasites.